It is contra-indicated in patients with pre-existing CNS depression or coma, bone-marrow suppression, or phaeochromocytoma. It should not be used in patients with impaired liver, kidney, cardiovascular, cerebrovascular, and respiratory function and in those with closed-angle glaucoma, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis or prostatic hypertrophy. Because of its sedative effect, patients should not drive or operate machinery. Also contraindicated in patients with suspected or established subcortical damage. Hypersensitivity to fluphenazine: Caution should be observed in patients with a history of sensitivity to other phenothiazines, as cross sensitivity may occur.
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